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bmp15  (Proteintech)


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    Proteintech bmp15
    a Representative ovarian images for TUNEL staining of F1–F3 offspring mice in Con and PrP groups at 12 w. b The number of TUNEL-positive cells per 1 mm 2 in ovarian sections of F1–F3 offspring mice in Con and PrP groups ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). c The number of abnormal mitochondria in mice ovaries of F1–F3 generation ( n = 3 biological replicates, two non-overlapping microscope fields per ovary). Data are presented as mean ± SEM (unpaired two-tailed t -test). d Representative TEM images of mice ovaries in F3 generation. Yellow arrow: synapses of granulosa cells. M: mitochondria. The experiment was repeated three times. e Schematic illustration of the ovulation induction. f Representative oocyte images after ovulation induction. g The number of oocytes of F1 and F3 offspring mice in Con and PrP groups after ovulation induction (F1 n = 9; F3 Con n = 6, PrP n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). h Representative IHC images showing immunoreactivity against <t>BMP15</t> in F1, F2 and F3 offspring ovaries. i IHC scores based on IOD/Area of anti-BMP15 in F1, F2 and F3 offspring ovaries ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). Source data are provided as a Source Data file. Figure 2e is created in BioRender. Wang, S. (2025) https://BioRender.com/bz8sq44 .
    Bmp15, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 15 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bmp15/product/Proteintech
    Average 93 stars, based on 15 article reviews
    bmp15 - by Bioz Stars, 2026-03
    93/100 stars

    Images

    1) Product Images from "Transgenerational inheritance of diminished ovarian reserve triggered by prenatal propylparaben exposure in mice"

    Article Title: Transgenerational inheritance of diminished ovarian reserve triggered by prenatal propylparaben exposure in mice

    Journal: Nature Communications

    doi: 10.1038/s41467-025-63440-z

    a Representative ovarian images for TUNEL staining of F1–F3 offspring mice in Con and PrP groups at 12 w. b The number of TUNEL-positive cells per 1 mm 2 in ovarian sections of F1–F3 offspring mice in Con and PrP groups ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). c The number of abnormal mitochondria in mice ovaries of F1–F3 generation ( n = 3 biological replicates, two non-overlapping microscope fields per ovary). Data are presented as mean ± SEM (unpaired two-tailed t -test). d Representative TEM images of mice ovaries in F3 generation. Yellow arrow: synapses of granulosa cells. M: mitochondria. The experiment was repeated three times. e Schematic illustration of the ovulation induction. f Representative oocyte images after ovulation induction. g The number of oocytes of F1 and F3 offspring mice in Con and PrP groups after ovulation induction (F1 n = 9; F3 Con n = 6, PrP n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). h Representative IHC images showing immunoreactivity against BMP15 in F1, F2 and F3 offspring ovaries. i IHC scores based on IOD/Area of anti-BMP15 in F1, F2 and F3 offspring ovaries ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). Source data are provided as a Source Data file. Figure 2e is created in BioRender. Wang, S. (2025) https://BioRender.com/bz8sq44 .
    Figure Legend Snippet: a Representative ovarian images for TUNEL staining of F1–F3 offspring mice in Con and PrP groups at 12 w. b The number of TUNEL-positive cells per 1 mm 2 in ovarian sections of F1–F3 offspring mice in Con and PrP groups ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). c The number of abnormal mitochondria in mice ovaries of F1–F3 generation ( n = 3 biological replicates, two non-overlapping microscope fields per ovary). Data are presented as mean ± SEM (unpaired two-tailed t -test). d Representative TEM images of mice ovaries in F3 generation. Yellow arrow: synapses of granulosa cells. M: mitochondria. The experiment was repeated three times. e Schematic illustration of the ovulation induction. f Representative oocyte images after ovulation induction. g The number of oocytes of F1 and F3 offspring mice in Con and PrP groups after ovulation induction (F1 n = 9; F3 Con n = 6, PrP n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). h Representative IHC images showing immunoreactivity against BMP15 in F1, F2 and F3 offspring ovaries. i IHC scores based on IOD/Area of anti-BMP15 in F1, F2 and F3 offspring ovaries ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). Source data are provided as a Source Data file. Figure 2e is created in BioRender. Wang, S. (2025) https://BioRender.com/bz8sq44 .

    Techniques Used: TUNEL Assay, Staining, Two Tailed Test, Microscopy



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    a Representative ovarian images for TUNEL staining of F1–F3 offspring mice in Con and PrP groups at 12 w. b The number of TUNEL-positive cells per 1 mm 2 in ovarian sections of F1–F3 offspring mice in Con and PrP groups ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). c The number of abnormal mitochondria in mice ovaries of F1–F3 generation ( n = 3 biological replicates, two non-overlapping microscope fields per ovary). Data are presented as mean ± SEM (unpaired two-tailed t -test). d Representative TEM images of mice ovaries in F3 generation. Yellow arrow: synapses of granulosa cells. M: mitochondria. The experiment was repeated three times. e Schematic illustration of the ovulation induction. f Representative oocyte images after ovulation induction. g The number of oocytes of F1 and F3 offspring mice in Con and PrP groups after ovulation induction (F1 n = 9; F3 Con n = 6, PrP n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). h Representative IHC images showing immunoreactivity against <t>BMP15</t> in F1, F2 and F3 offspring ovaries. i IHC scores based on IOD/Area of anti-BMP15 in F1, F2 and F3 offspring ovaries ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). Source data are provided as a Source Data file. Figure 2e is created in BioRender. Wang, S. (2025) https://BioRender.com/bz8sq44 .
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    a Representative ovarian images for TUNEL staining of F1–F3 offspring mice in Con and PrP groups at 12 w. b The number of TUNEL-positive cells per 1 mm 2 in ovarian sections of F1–F3 offspring mice in Con and PrP groups ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). c The number of abnormal mitochondria in mice ovaries of F1–F3 generation ( n = 3 biological replicates, two non-overlapping microscope fields per ovary). Data are presented as mean ± SEM (unpaired two-tailed t -test). d Representative TEM images of mice ovaries in F3 generation. Yellow arrow: synapses of granulosa cells. M: mitochondria. The experiment was repeated three times. e Schematic illustration of the ovulation induction. f Representative oocyte images after ovulation induction. g The number of oocytes of F1 and F3 offspring mice in Con and PrP groups after ovulation induction (F1 n = 9; F3 Con n = 6, PrP n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). h Representative IHC images showing immunoreactivity against <t>BMP15</t> in F1, F2 and F3 offspring ovaries. i IHC scores based on IOD/Area of anti-BMP15 in F1, F2 and F3 offspring ovaries ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). Source data are provided as a Source Data file. Figure 2e is created in BioRender. Wang, S. (2025) https://BioRender.com/bz8sq44 .
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    a Representative ovarian images for TUNEL staining of F1–F3 offspring mice in Con and PrP groups at 12 w. b The number of TUNEL-positive cells per 1 mm 2 in ovarian sections of F1–F3 offspring mice in Con and PrP groups ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). c The number of abnormal mitochondria in mice ovaries of F1–F3 generation ( n = 3 biological replicates, two non-overlapping microscope fields per ovary). Data are presented as mean ± SEM (unpaired two-tailed t -test). d Representative TEM images of mice ovaries in F3 generation. Yellow arrow: synapses of granulosa cells. M: mitochondria. The experiment was repeated three times. e Schematic illustration of the ovulation induction. f Representative oocyte images after ovulation induction. g The number of oocytes of F1 and F3 offspring mice in Con and PrP groups after ovulation induction (F1 n = 9; F3 Con n = 6, PrP n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). h Representative IHC images showing immunoreactivity against <t>BMP15</t> in F1, F2 and F3 offspring ovaries. i IHC scores based on IOD/Area of anti-BMP15 in F1, F2 and F3 offspring ovaries ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). Source data are provided as a Source Data file. Figure 2e is created in BioRender. Wang, S. (2025) https://BioRender.com/bz8sq44 .
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    a Representative ovarian images for TUNEL staining of F1–F3 offspring mice in Con and PrP groups at 12 w. b The number of TUNEL-positive cells per 1 mm 2 in ovarian sections of F1–F3 offspring mice in Con and PrP groups ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). c The number of abnormal mitochondria in mice ovaries of F1–F3 generation ( n = 3 biological replicates, two non-overlapping microscope fields per ovary). Data are presented as mean ± SEM (unpaired two-tailed t -test). d Representative TEM images of mice ovaries in F3 generation. Yellow arrow: synapses of granulosa cells. M: mitochondria. The experiment was repeated three times. e Schematic illustration of the ovulation induction. f Representative oocyte images after ovulation induction. g The number of oocytes of F1 and F3 offspring mice in Con and PrP groups after ovulation induction (F1 n = 9; F3 Con n = 6, PrP n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). h Representative IHC images showing immunoreactivity against <t>BMP15</t> in F1, F2 and F3 offspring ovaries. i IHC scores based on IOD/Area of anti-BMP15 in F1, F2 and F3 offspring ovaries ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). Source data are provided as a Source Data file. Figure 2e is created in BioRender. Wang, S. (2025) https://BioRender.com/bz8sq44 .
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    a Representative ovarian images for TUNEL staining of F1–F3 offspring mice in Con and PrP groups at 12 w. b The number of TUNEL-positive cells per 1 mm 2 in ovarian sections of F1–F3 offspring mice in Con and PrP groups ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). c The number of abnormal mitochondria in mice ovaries of F1–F3 generation ( n = 3 biological replicates, two non-overlapping microscope fields per ovary). Data are presented as mean ± SEM (unpaired two-tailed t -test). d Representative TEM images of mice ovaries in F3 generation. Yellow arrow: synapses of granulosa cells. M: mitochondria. The experiment was repeated three times. e Schematic illustration of the ovulation induction. f Representative oocyte images after ovulation induction. g The number of oocytes of F1 and F3 offspring mice in Con and PrP groups after ovulation induction (F1 n = 9; F3 Con n = 6, PrP n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). h Representative IHC images showing immunoreactivity against <t>BMP15</t> in F1, F2 and F3 offspring ovaries. i IHC scores based on IOD/Area of anti-BMP15 in F1, F2 and F3 offspring ovaries ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). Source data are provided as a Source Data file. Figure 2e is created in BioRender. Wang, S. (2025) https://BioRender.com/bz8sq44 .
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    a Representative ovarian images for TUNEL staining of F1–F3 offspring mice in Con and PrP groups at 12 w. b The number of TUNEL-positive cells per 1 mm 2 in ovarian sections of F1–F3 offspring mice in Con and PrP groups ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). c The number of abnormal mitochondria in mice ovaries of F1–F3 generation ( n = 3 biological replicates, two non-overlapping microscope fields per ovary). Data are presented as mean ± SEM (unpaired two-tailed t -test). d Representative TEM images of mice ovaries in F3 generation. Yellow arrow: synapses of granulosa cells. M: mitochondria. The experiment was repeated three times. e Schematic illustration of the ovulation induction. f Representative oocyte images after ovulation induction. g The number of oocytes of F1 and F3 offspring mice in Con and PrP groups after ovulation induction (F1 n = 9; F3 Con n = 6, PrP n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). h Representative IHC images showing immunoreactivity against <t>BMP15</t> in F1, F2 and F3 offspring ovaries. i IHC scores based on IOD/Area of anti-BMP15 in F1, F2 and F3 offspring ovaries ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). Source data are provided as a Source Data file. Figure 2e is created in BioRender. Wang, S. (2025) https://BioRender.com/bz8sq44 .
    Anti Bmp15 Antibody, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    a Representative ovarian images for TUNEL staining of F1–F3 offspring mice in Con and PrP groups at 12 w. b The number of TUNEL-positive cells per 1 mm 2 in ovarian sections of F1–F3 offspring mice in Con and PrP groups ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). c The number of abnormal mitochondria in mice ovaries of F1–F3 generation ( n = 3 biological replicates, two non-overlapping microscope fields per ovary). Data are presented as mean ± SEM (unpaired two-tailed t -test). d Representative TEM images of mice ovaries in F3 generation. Yellow arrow: synapses of granulosa cells. M: mitochondria. The experiment was repeated three times. e Schematic illustration of the ovulation induction. f Representative oocyte images after ovulation induction. g The number of oocytes of F1 and F3 offspring mice in Con and PrP groups after ovulation induction (F1 n = 9; F3 Con n = 6, PrP n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). h Representative IHC images showing immunoreactivity against BMP15 in F1, F2 and F3 offspring ovaries. i IHC scores based on IOD/Area of anti-BMP15 in F1, F2 and F3 offspring ovaries ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). Source data are provided as a Source Data file. Figure 2e is created in BioRender. Wang, S. (2025) https://BioRender.com/bz8sq44 .

    Journal: Nature Communications

    Article Title: Transgenerational inheritance of diminished ovarian reserve triggered by prenatal propylparaben exposure in mice

    doi: 10.1038/s41467-025-63440-z

    Figure Lengend Snippet: a Representative ovarian images for TUNEL staining of F1–F3 offspring mice in Con and PrP groups at 12 w. b The number of TUNEL-positive cells per 1 mm 2 in ovarian sections of F1–F3 offspring mice in Con and PrP groups ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). c The number of abnormal mitochondria in mice ovaries of F1–F3 generation ( n = 3 biological replicates, two non-overlapping microscope fields per ovary). Data are presented as mean ± SEM (unpaired two-tailed t -test). d Representative TEM images of mice ovaries in F3 generation. Yellow arrow: synapses of granulosa cells. M: mitochondria. The experiment was repeated three times. e Schematic illustration of the ovulation induction. f Representative oocyte images after ovulation induction. g The number of oocytes of F1 and F3 offspring mice in Con and PrP groups after ovulation induction (F1 n = 9; F3 Con n = 6, PrP n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). h Representative IHC images showing immunoreactivity against BMP15 in F1, F2 and F3 offspring ovaries. i IHC scores based on IOD/Area of anti-BMP15 in F1, F2 and F3 offspring ovaries ( n = 5 biological replicates). Data are presented as mean ± SEM (unpaired two-tailed t -test). Source data are provided as a Source Data file. Figure 2e is created in BioRender. Wang, S. (2025) https://BioRender.com/bz8sq44 .

    Article Snippet: The Antibodies were purchased from different companies: Cell Signaling Technology for ERK (Extracellular Signal-Regulated Kinase; 4695T), p-ERK (Phosphorylated ERK; 4370T), p38 (p38 Mitogen-Activated Protein Kinase; 8690T), p-p38 (Phosphorylated p38; 4511T), JNK (c-Jun N-terminal Kinase; 9252T), and p-JNK (Phosphorylated JNK; 4668T); Abclonal for β-ACTIN (AC038), active-Caspase3 (A19654), BCL-2 (A19693), BAX (A12009), SOD2 (A19576), BMP15 (A7321), CAT (A11777), HSD17B7 (A17157), and CTSK (A1782); Proteintech for FGF18 (60341-1-lg); Immunoway for RhoBTB1 (YT4084); Servicebio for HRP conjugated goat anti-rabbit IgG (GB23303), and Alexa Fluor® 488-conjugated goat anti-rabbit IgG (GB25303).

    Techniques: TUNEL Assay, Staining, Two Tailed Test, Microscopy